The Bile Acid Nuclear Receptor.
- Intercept Pharmaceuticals
The nuclear receptor FXR is a bile acid receptor located in the liver, intestine, kidney, and adipose tissue. Upon activation FXR acts as a regulator of many biological processes, including: bile acid metabolism, inflammation, fibrosis, glucose metabolism, and lipid metabolism. FXR is thus an attractive target for new drugs to treat dyslipidemia and liver disorders, such as NAFLD and hypertriglyceridemia.
A FXR agonist identified by Tes Pharma is currently being evaluated in Phase 1 clinical trials. The compound appears to be a more selective FXR agonist than Obeticholic Acid (OCA) and has shown potential anti-fibrotic and anti-inflammatory effects in animal models.