Publications

α-Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) Inhibitors as Novel Modulators of De Novo Nicotinamide Adenine Dinucleotide (NAD+) Biosynthesis.
Pellicciari R, Liscio P, Giacchè N, De Franco F, Carotti A, Robertson J, Cialabrini L, Katsyuba E, Raffaelli N, Auwerx J.
J Med Chem. 2018 Jan 26. doi: 10.1021/acs.jmedchem.7b01254.

Synthesis, physicochemical properties, and biological activity of bile acids 3-glucuronides: Novel insights into bile acid signalling and detoxification.
Mostarda S, Passeri D, Carotti A, Cerra B, Colliva C, Benicchi T, Macchiarulo A, Pellicciari R, Gioiello A.
Eur J Med Chem. 2017 Dec 11;144:349-358. doi: 10.1016/j.ejmech.2017.12.034.

Synthetic Lethality Triggered by Combining Olaparib with BRCA2-Rad51 Disruptors.
Falchi F, Giacomini E, Masini T, Boutard N, Di Ianni L, Manerba M, Farabegoli F, Rossini L, Robertson J, Minucci S, Pallavicini I, Di Stefano G, Roberti M, Pellicciari R, Cavalli A.
ACS Chem Biol. 2017 Oct 20;12(10):2491-2497. doi: 10.1021/acschembio.7b00707.

Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2: Structure-Activity Relationship, X-ray Crystal Structure, and Anticancer Activity.
Moniot S, Forgione M, Lucidi A, Hailu GS, Nebbioso A, Carafa V, Baratta F, Altucci L, Giacché N, Passeri D, Pellicciari R, Mai A, Steegborn C, Rotili D.
J Med Chem. 2017 Mar 23;60(6):2344-2360. doi: 10.1021/acs.jmedchem.6b01609.

Discovery of 3α,7α,11β-Trihydroxy-6α-ethyl-5β-cholan-24-oic Acid (TC-100), a Novel Bile Acid as Potent and Highly Selective FXR Agonist for Enterohepatic Disorders.
Pellicciari R, Passeri D, De Franco F, Mostarda S, Filipponi P, Colliva C, Gadaleta RM, Franco P, Carotti A, Macchiarulo A, Roda A, Moschetta A, Gioiello A.
J Med Chem. 2016 Oct 4. doi: 10.1021/acs.jmedchem.6b01126.

Concepts and Molecular Aspects in the Polypharmacology of PARP-1 Inhibitors.
Passeri D, Camaioni E, Liscio P, Sabbatini P, Ferri M, Carotti A, Giacchè N, Pellicciari R, Gioiello A, Macchiarulo A.
ChemMedChem. 2016 Jun 20;11(12):1219-26. doi: 10.1002/cmdc.201500391.

The glucocorticoid mometasone furoate is a novel FXR ligand that decreases inflammatory but not metabolic gene expression.
Bijsmans IT, Guercini C, Ramos Pittol JM, Omta W, Milona A, Lelieveld D, Egan DA, Pellicciari R, Gioiello A, van Mil SW.
Sci Rep. 2015 Sep 15;5:14086. doi: 10.1038/srep14086.

Beyond bile acids: targeting Farnesoid X Receptor (FXR) with natural and synthetic ligands.
Carotti A, Marinozzi M, Custodi C, Cerra B, Pellicciari R, Gioiello A, Macchiarulo A.
Curr Top Med Chem. 2014;14(19):2129-42. doi: 10.2174/1568026614666141112094058.

Glucuronidation of bile acids under flow conditions: design of experiments and Koenigs Knorr reaction optimization.
Mostarda S, Filipponi P, Sardella R, Venturoni F, Natalini B, Pellicciari R, Gioiello A.
Org Biomol Chem. 2014 Dec 21;12(47):9592-600. doi: 10.1039/c4ob01911c.

Continuous Flow Synthesis of Thieno[2,3-c]isoquinolin-5(4H)-one Scaffold: A Valuable Source of PARP-1 Inhibitors
Filipponi P, Ostacolo C, Novellino E, Pellicciari R, and Gioiello A.
Org. Process Res. Dev. 2014 May14;18(11):1345–53. doi: 10.1021/op500074h.

Semisynthetic bile acid FXR and TGR5 agonists: physicochemical properties, pharmacokinetics, and metabolism in the rat.
Roda A, Pellicciari R, Gioiello A, Neri F, Camborata C, Passeri D, De Franco F, Spinozzi S, Colliva C, Adorini L, Montagnani M, Aldini R.
J Pharmacol Exp Ther. 2014 Jul;350(1):56-68. doi: 10.1124/jpet.114.214650.

Conformational properties of cholic acid, a lead compound at the crossroads of bile acid inspired drug discovery
Gioiello A, Venturoni F, Tamimi S, Custodi C, Pellicciari R, Macchiarulo A.
MedChemCommun. 2014 Mar17;5:750-7. doi: 10.1039/C4MD00024B.

Design, synthesis, crystallographic studies, and preliminary biological appraisal of newsubstituted triazolo[4,3-b]pyridazin-8-amine derivatives as tankyrase inhibitors.
Liscio P, Carotti A, Asciutti S, Karlberg T, Bellocchi D, Llacuna L, Macchiarulo A, Aaronson SA, Schüler H, Pellicciari R, Camaioni E.
J Med Chem. 2014 Mar 27;57(6):2807-12. doi: 10.1021/jm401356t.

Synthesis of atypical bile acids for use as investigative tools for the genetic defect of 3β-hydroxy-Δ(5)-C27-steroid oxidoreductase deficiency.
Gioiello A, Cerra B, Zhang W, Vallerini GP, Costantino G, De Franco F, Passeri D, Pellicciari R, Setchell KD.
J Steroid Biochem Mol Biol. 2014 Oct;144 Pt B:348-60. doi: 10.1016/j.jsbmb.2014.06.008.

Investigating the allosteric reverse signalling of PARP inhibitors with microsecond molecular dynamic simulations and fluorescence anisotropy.
Marchand JR, Carotti A, Passeri D, Filipponi P, Liscio P, Camaioni E, Pellicciari R, Gioiello A, Macchiarulo A.
Biochim Biophys Acta. 2014 Oct;1844(10):1765-72. doi: 10.1016/j.bbapap.2014.07.012.

Scaffold hopping approach on the route to selective tankyrase inhibitors.
Liscio P, Carotti A, Asciutti S, Ferri M, Pires MM, Valloscuro S, Ziff J, Clark NR, Macchiarulo A, Aaronson SA, Pellicciari R, Camaioni E.
Eur J Med Chem. 2014 Nov 24;87:611-23. doi: 10.1016/j.ejmech.2014.10.007.

Synthesis and quantitative structure-property relationships of side chain-modifiedhyodeoxycholic acid derivatives.
Sabbatini P, Filipponi P, Sardella R, Natalini B, Nuti R, Macchiarulo A, Pellicciari R, Gioiello A.
Molecules. 2013 Aug 30;18(9):10497-513. doi: 10.3390/molecules180910497.

Probing the Binding Site of Bile Acids in TGR5.
Macchiarulo A, Gioiello A, Thomas C, Pols TW, Nuti R, Ferrari C, Giacchè N, De Franco F, Pruzanski M, Auwerx J, Schoonjans K, Pellicciari R.
ACS Med Chem Lett. 2013 Oct 15;4(12):1158-62. doi: 10.1021/ml400247k.

From polypharmacology to target specificity: the case of PARP inhibitors.
Liscio P, Camaioni E, Carotti A, Pellicciari R, Macchiarulo A.
Curr Top Med Chem. 2013;13(23):2939-54. doi: 10.2174/15680266113136660209

Asymmetric synthesis of the four diastereoisomers of a novel non-steroidal farnesoid Xreceptor (FXR) agonist: role of the chirality on the biological activity.
Marinozzi M, Carotti A, Sardella R, Buonerba F, Ianni F, Natalini B, Passeri D, Rizzo G, Pellicciari R.
Bioorg Med Chem. 2013 Jul 1;21(13):3780-9. doi: 10.1016/j.bmc.2013.04.038.

Exploring the effect of PARP-1 flexibility in docking studies.
Antolin AA, Carotti A, Nuti R, Hakkaya A, Camaioni E, Mestres J, Pellicciari R, Macchiarulo A.
J Mol Graph Model. 2013 Sep;45:192-201. doi: 10.1016/j.jmgm.2013.08.006.